The Central and Peripheral Neural Nervous Systems

Leptin-sensitive sensory nerves innervate white fat

First published April 23, 2013; doi:10.1152/ajpendo.00021.2013.—Leptin, the primary white adipose tissue (WAT) adipokine, is thought to convey lipid reserve information to the brain via the circulation. Because WAT responds to environmental/internal signals in a fat pad-specific (FPS) manner, systemic signals such as leptin would fail to communicate such distinctive information. Saturation of brain leptin transport… more »

Why study obesity and the central and peripheral neural nervous systems

During development, nerve cells within the central nervous system and neurons making connections with target tissues outside of the central nervous system have to make a series of correct choices to establish appropriate connections.. The functional incorporation of WAT (above) or BAT (below) transplanted tissues into regular physiological processes also requires the directed re-innervation by… more »